Centrogenic Cardiac Arrhythmia Induced by Aconitine: A New “Model” for Screening of Anti-Arrhythmic Drugs
نویسندگان
چکیده
منابع مشابه
Aconitine-induced cardiac arrhythmia.
Renewed interest in the pharmacological action of aconitine has followed the work of Sherf (1947), Prinzmetal et al. (1950 and 1951), and Brown and Acheson (1952). Its use in experimental medicine produces stimulus formation in the dog's heart with auricular tachycardia and in certain circumstances ventricular tachycardia and fibrillation: it has become a useful tool in the hands of the researc...
متن کاملArctigenin, a potential anti-arrhythmic agent, inhibits aconitine-induced arrhythmia by regulating multi-ion channels.
BACKGROUND/AIMS Arctigenin possesses biological activities, but its underlying mechanisms at the cellular and ion channel levels are not completely understood. Therefore, the present study was designed to identify the anti-arrhythmia effect of arctigenin in vivo, as well as its cellular targets and mechanisms. METHODS A rat arrhythmia model was established via continuous aconitine infusion, a...
متن کاملAn experimental investigation on the antiarrhythmic activity of antiepileptic agents.
Several groups of drugs have been shown to possess antiarrhythmic activity. Some of them e.g. quinidine, procainamide, local anaesthetics, β-receptor blocking agents and diphenylhydantoin etc. have achieved a clinical status as antiarrhythmic drugs. Diphenyl hydantoin (dilantin) an anticonvulsant has been successfully employed for the supression of ventricular arrhythmias due to digitalis ...
متن کاملInteractions of Rosiglitazone and Anti-Arrhythmic Drugs in Animal Model
BACKGROUND Diabetes increases the risk of vascular problems by two times compared with a healthy individual, with deposition of fats in blood vessel and this includes cardiovascular disease. The treatment regimens for patients suffering from both diseases generally include prolonged use of anti-diabetic drugs for diabetes and anti-arrhythmic drugs for cardiac arrhythmias. AIM The aim of the s...
متن کاملEffect of a new ultrashort betalytic agent on aconitine-induced arrhythmia.
The anti-arrhythmic effect was tested on the model of aconitine-induced arrhythmia. The experiment was performed in vivo with 31 male Wistar laboratory rats. Group A was first administered aconitine and, after the onset of the first sinus rhythm disorders, the 44Bu compound was administered. Group B was first administered the 44Bu compound and only after that the aconitine. The control group wa...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1971
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)36169-4